Euphorbia antiquorum L. root in diabetic rats
نویسندگان
چکیده
Background/Aim: To determine the anti-hyperglycemic effect of Euphorbia antiquorum L. root. Materials and Methods: The study evaluates the anti-hyperglycemic effect of E. antiquorum root in streptozotocin-nicotinamide-induced Type 2 diabetes mellitus and fructose-induced insulin resistance models. Alcohol and aqueous extracts of E. antiquorum root were administered at doses 200 and 400 mg/kg p.o. Serum levels of glucose, total cholesterol, triglycerides, glycosylated hemoglobin (GHb), and hepatic levels of malondialdehyde, glutathione, and glycogen were estimated. Results: Treatment with the alcohol and aqueous extracts of E. antiquorum roots resulted in significant (P < 0.001) lowering of serum blood glucose and GHb levels in both the models. Flavonoids, phenolic compounds, and glycosides were detected in the preliminary phytochemical screening. Conclusion: Root of E. antiquorum showed promising anti-hyperglycemic effect which may be due to the presence of important phytochemicals.
منابع مشابه
Toxicity of Euphorbia antiquorum latex extract to fresh water fish Poecilia reticulata
The use of plant extract as poisons for hunting and fishing is common among fishermen of various countries. Fish poisons from plants are also known as piscicides or inchthyotoxins. Several plant species are known to possess bioactive compounds that are toxic to fish. The piscicidal activity of methanolic latex extracts of Euphorbia antiquorum plant belonging to Family: Euphorbiaceae against Poe...
متن کامل[Terpenoids from Euphorbia antiquorum L.].
To study the chemical constituents of Euphorbia antiquorum L., the constituents were isolated with normal-phase and reverse-phase silica gel column chromatography and their structures were elucidated on the basis of spectroscopic data. Seven terpenoids were obtained from EtOAc extract of E. antiquoru L. They were identified as antiquorine A (1), antiquorine B (2), ent-13S-hydroxy-16-atisene-3,1...
متن کاملAntidiabetic and antihyperlipidemic effect of Euphorbia hirta in streptozotocin induced diabetic rats
The present study was aimed to evaluate the anti diabetic activity potential of Euphorbia hirta leaves against streptozotocin (STZ) induced experimental rats. Ethanolic extract of E. hirta leaves was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Euphorbia hirta (400 mg/kg b. wt)...
متن کاملHydro-alcoholic extract of the root of Prangos ferulacea (L.) Lindl can improve serum glucose and lipids in alloxan-induced diabetic rats
Objectives: Diabetes mellitusmanifests itself in a wide variety of complications and the symptoms of this disease are multifactorial. Previousstudies proved that this disease is directly related to hyperglycemia and hyperlipidemia. The aim of this study was to investigate the hypoglycemic and hypolipidemic effects of hydroalcoholic extract of Prangos frulacea (L.)Lindlin alloxan-induced diabeti...
متن کاملAntidiabetic and antihyperlipidemic activity of Euphorbia thymifolia L. extracts on streptozotocin-nicotinamide induced type 2 diabetic rats
Article history: Received on: 21/03/2017 Accepted on: 25/05/2017 Available online: 30/08/2017 The present investigation is aimed to elucidate the hypoglycaemic and hypolipidemic effect of the aqueous and methanol extract of Euphorbia thymifolia (ET) aerial parts in streptozotocin-nicotinamide (STZ-NA) induced diabetic rats. Diabetes was induced by administration of STZ (65 mg/kg, i.p.) followed...
متن کامل